Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen

Author:

Rissanen Ilona123,Krumm Stefanie A.4,Stass Robert1,Whitaker Annalis56,Voss James E.7,Bruce Emily A.58,Rothenberger Sylvia9,Kunz Stefan9ORCID,Burton Dennis R.710,Huiskonen Juha T.123,Botten Jason W.58,Bowden Thomas A.1ORCID,Doores Katie J.4ORCID

Affiliation:

1. Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

2. Institute of Biotechnology and Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland

3. Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland

4. Department of Infectious Diseases, King's College London, London, United Kingdom

5. Division of Immunobiology, Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA

6. Cellular, Molecular, and Biomedical Sciences Graduate Program, University of Vermont, Burlington, Vermont, USA

7. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA

8. Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA

9. Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

10. Ragon Institute of MGH, Harvard, and MIT, Cambridge, Massachusetts, USA

Abstract

The spillover of pathogenic hantaviruses from rodent reservoirs into the human population poses a continued threat to human health. Here, we show that a recombinant form of the Hantaan virus (HTNV) surface-displayed glycoprotein, Gn, elicits a neutralizing antibody response in rabbits.

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3