Sequential Transmission of Influenza Viruses in Ferrets Does Not Enhance Infectivity and Does Not Predict Transmissibility in Humans

Author:

Sutton Troy C.1ORCID,Lamirande Elaine W.1,Patel Devanshi R.2,Johnson Katherine E. E.3,Czako Rita1,Ghedin Elodie3ORCID,Lee Raphael T. C.4,Maurer-Stroh Sebastian456,Subbarao Kanta1ORCID

Affiliation:

1. Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, USA

2. Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania, USA

3. Center for Genomics and Systems Biology, New York University, New York, New York, USA

4. Infectious Diseases Laboratories (ID Labs), Agency for Science Technology and Research (A*STAR), Singapore

5. Bioinformatics Institute (BII), Agency for Science Technology and Research (A*STAR), Singapore

6. Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

Abstract

Airborne transmission in ferrets is used to gauge the pandemic potential of emerging influenza viruses; however, some emerging influenza viruses that transmit between ferrets do not spread between humans. Therefore, we evaluated sequential rounds of airborne transmission in ferrets as a strategy to enhance the predictive accuracy of the ferret model.

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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