Molecular Signatures of Inflammatory Profile and B-Cell Function in Patients with Severe Fever with Thrombocytopenia Syndrome

Author:

Park Angela1,Park Su-Jin234,Jung Kyle L.15,Kim Se Mi23,Kim Eun-Ha23,Kim Young-Il23ORCID,Foo Suan-Sin15,Kim Sunghyun1,Kim Seong-Gyu23,Yu Kwang-Min23,Choi Younho15,Kim Ji Yeun6,Baek Yun Hee23,Song Min-Suk23ORCID,Kim Seung Ryul2,Kim Seok-Yong2,Jeong Hye Won2,Kim Sung-Han6,Jung Jae U.15ORCID,Choi Young Ki23ORCID

Affiliation:

1. Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

2. College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea

3. Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea

4. Division of Life Science, Research Institute of Life Science, Gyeongsang National University, Jinju, Republic of Korea

5. Department of Cancer Biology and Global Center for Pathogens Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

6. Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Abstract

SFTSV is an emerging virus discovered in China in 2009; it has since spread to other countries in East Asia. Although the fatality rates of SFTSV infection range from 5.3% to as high as 27%, the mechanisms underlying clinical manifestations are largely unknown.

Funder

Government wide R&D Fund project for infectious disease research (GFID), Republic of Korea

HHS | National Institutes of Health

National Research Foundation of Korea

Korea Research Institute of Bioscience and Biotechnology

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference43 articles.

1. NCBI Taxonomy: a comprehensive update on curation, resources and tools

2. Severe fever with thrombocytopenia syndrome (SFTS) in Japan, as of June 2019;National Institute of Infectious Diseases;Infect Agents Surveill Rep,2019

3. KCDA. 2020. Infectious Disease Portal. http://www.cdc.go.kr/npt/biz/npp/ist/bass/bassDissStatsMain.do.

4. Spatial and temporal analysis of severe fever with thrombocytopenia syndrome in Zhejiang Province, China, 2011 - 2015

5. Current status of severe fever with thrombocytopenia syndrome in China

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