Pharmacokinetic Model for Cefuroxime Dosing during Cardiac Surgery under Cardiopulmonary Bypass-Reference-Cited by-同舟云学术

Pharmacokinetic Model for Cefuroxime Dosing during Cardiac Surgery under Cardiopulmonary Bypass

Published:2020-11-17 Issue:12 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lanoiselée J.¹²^ORCID,Zufferey P. J.¹²³,Hodin S.⁴,Tamisier N.²,Gergelé L.²,Palao J. C.²,Campisi S.⁵,Molliex S.²,Morel J.²,Delavenne X.¹⁴⁶,Ollier E.¹³

Affiliation:

1. INSERM, U1059, Dysfonction Vasculaire et Hémostase, Saint-Etienne, France

2. Département d’Anesthésie-Réanimation, CHU de Saint-Etienne, Saint-Etienne, France

3. Unité de Recherche Clinique Innovation et Pharmacologie, CHU de Saint-Etienne, Saint-Etienne, France

4. Laboratoire de Pharmacologie Toxicologie, CHU de Saint-Etienne, Saint-Etienne, France

5. Service de Chirurgie Cardio-Vasculaire, CHU de Saint-Etienne, Saint-Etienne, France

6. Université de Lyon, Saint-Etienne, France

Abstract

Cefuroxime (CXM) is an antibiotic recommended for surgical site infection prevention in cardiac surgery. However, the dosing regimens commonly used do not sustain therapeutic concentrations throughout surgery. The aim of this study was to conduct a population analysis of CXM pharmacokinetics (PK), and to propose an optimized dosing regimen. Adult patients undergoing cardiac surgery under cardiopulmonary bypass (CPB) received a 1,500 mg CXM intravenous bolus followed by a 750 mg bolus at CPB priming, then every 2 h thereafter.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01687-20

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