Antimicrobial Susceptibility of Mycoplasma pneumoniae Isolates and Molecular Analysis of Macrolide-Resistant Strains from Shanghai, China-Reference-Cited by-全球学者库

Antimicrobial Susceptibility of Mycoplasma pneumoniae Isolates and Molecular Analysis of Macrolide-Resistant Strains from Shanghai, China

Published:2009-05 Issue:5 Volume:53 Page:2160-2162
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Liu Yang¹,Ye Xinyu¹,Zhang Hong²,Xu Xiaogang¹,Li Wanhua²,Zhu Demei¹,Wang Minggui¹³

Affiliation:

1. Institute of Antibiotics, Huashan Hospital

2. Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai 200040, China

3. Institute of Biomedical Sciences, Fudan University, Shanghai 200040, China

Abstract

ABSTRACT Fifty-three Mycoplasma pneumoniae strains were isolated from pediatric patients in Shanghai, China, from October 2005 to February 2008. Of 53 clinical isolates, 44 (83%) were resistant to erythromycin (MICs of >128 μg/ml for all 44 strains), azithromycin, and clarithromycin. All macrolide-resistant M. pneumoniae strains harbored an A-to-G transition mutation at position 2063 in 23S rRNA genes. Forty-five (85%) clinical isolates were classified into the P1 gene restriction fragment length polymorphism type I, and six (11%) were type II.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01684-08

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