Affiliation:
1. Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032
Abstract
Pseudomonas aeruginosa
exposed to silver sulfadiazine (AgSu) were examined in an electron microscope. The treated cells were distorted in shape, and structures (blebs) protruded from the cell surface. These “blebs” appeared to arise from the cell wall. A strain of
P. aeruginosa
resistant to AgSu did not display these changes. Upon exposure of
P. aeruginosa
to silver nitrate, none of these changes was seen; rather, such cells are characterized by large, central aggregations of nuclear material. The results are consistent with previous findings which suggested that AgSu acted at the cell surface.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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