Transforming Growth Factor β Signaling Promotes HIV-1 Infection in Activated and Resting Memory CD4 <sup>+</sup> T Cells-Reference-Cited by-同舟云学术

Transforming Growth Factor β Signaling Promotes HIV-1 Infection in Activated and Resting Memory CD4 ⁺ T Cells

Published:2023-05-31 Issue:5 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Yim Lok Yan¹²,Lam Ka Shing¹²,Luk Tsz-Yat¹²,Mo Yufei¹²,Lu Xiaofan³,Wang Jinlin¹²⁴,Cheung Ka-Wai¹²,Lui Grace Chung Yan⁵,Chan Denise Pui Chung⁶,Wong Bonnie Chun Kwan⁵,Lau Thomas Tsz-Kan¹²,Ngan Chiu Bong¹²,Zhou Dongyan¹²,Wong Yik Chun¹²,Tan Zhiwu¹²,Liu Li¹²^ORCID,Wu Hao³,Zhang Tong³,Lee Shui Shan⁶,Chen Zhiwei¹²⁴⁷⁸^ORCID

Affiliation:

1. AIDS Institute, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (SAR), People’s Republic of China

2. Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, People’s Republic of China

3. Beijing Key Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, People’s Republic of China

4. Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, People’s Republic of China

5. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

6. Stanley Ho Centre for Emerging Infectious Diseases, Postgraduate Education Centre, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, People’s Republic of China

7. State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong SAR, People’s Republic of China

8. Center for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong SAR, People’s Republic of China

Abstract

Incomplete eradication of HIV-1 latency reservoirs remains the major hurdle in achieving a complete HIV/AIDS cure. Dissecting the facilitator of latency reservoir establishment may aid the discovery of druggable targets for HIV-1 cure.

Funder

FHB | Health and Medical Research Fund

Research Grants Council, University Grants Committee

HKU | Li Ka Shing Faculty of Medicine, University of Hong Kong

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00270-23

Reference52 articles.

1. Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs

2. The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies

3. Memory CD4 + T-Cells Expressing HLA-DR Contribute to HIV Persistence During Prolonged Antiretroviral Therapy

4. Resting Regulatory CD4 T Cells: A Site of HIV Persistence in Patients on Long-Term Effective Antiretroviral Therapy

5. Reduction of HIV-1 Reservoir Size and Diversity After 1 Year of cART Among Brazilian Individuals Starting Treatment During Early Stages of Acute Infection

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