HIV-1 Preintegration Complex Preferentially Integrates the Viral DNA into Nucleosomes Containing Trimethylated Histone 3-Lysine 36 Modification and Flanking Linker DNA-Reference-Cited by-同舟云学术

HIV-1 Preintegration Complex Preferentially Integrates the Viral DNA into Nucleosomes Containing Trimethylated Histone 3-Lysine 36 Modification and Flanking Linker DNA

Published:2022-09-28 Issue:18 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sapp Nicklas¹²³,Burge Nathaniel⁴⁵,Cox Khan⁴⁵⁶,Prakash Prem¹²,Balasubramaniam Muthukumar¹²,Thapa Santosh¹²,Christensen Devin⁷,Li Min⁶,Linderberger Jared⁸,Kvaratskhelia Mamuka⁸^ORCID,Pandhare Jui¹³⁹,Craigie Robert⁶,Poirier Michael G.⁹⁴⁵,Dash Chandravanu¹²^ORCID

Affiliation:

1. The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee, USA

2. Department of Biochemistry, Cancer Biology, Pharmacology, and Neuroscience, Meharry Medical College, Nashville, Tennessee, USA

3. School of Graduate Studies and Research, Meharry Medical College, Nashville, Tennessee, USA

4. Department of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio, USA

5. Department of Physics, Ohio State University, Columbus, Ohio, USA

6. Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA

7. Department of Biochemistry, University of Utah, Salt Lake City, Utah, USA

8. Division of Infectious Diseases, University of Colorado, Aurora, Colorado, USA

9. Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, Tennessee, USA

Abstract

HIV-1 infection is dependent on integration of the viral DNA into the host chromosomes. The preintegration complex (PIC) containing the viral DNA, the virally encoded integrase (IN) enzyme, and other viral/host factors carries out HIV-1 integration.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01011-22

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