Cryptococcus neoformans - Infected Macrophages Release Proinflammatory Extracellular Vesicles: Insight into Their Components by Multi-omics

Author:

Zhang Lei1234,Zhang Keming12,Li Hang12,Coelho Carolina5,de Souza Gonçalves Diego6,Fu Man Shun7,Li Xinhua8,Nakayasu Ernesto S.9ORCID,Kim Young-Mo9ORCID,Liao Wanqing12,Pan Weihua12ORCID,Casadevall Arturo4ORCID

Affiliation:

1. Department of Dermatology and Venereology, Changzheng Hospital, Second Military Medical University, Shanghai, China

2. Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai Institute of Medical Mycology, Changzheng Hospital, Second Military Medical University, Shanghai, China

3. Department of Dermatology, Shaanxi Provincial People’s Hospital, Xi’an, China

4. Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA

5. MRC Centre for Medical Mycology, University of Exeter, Exeter, United Kingdom

6. Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Pós-Graduaçao em Doença Infecciosas e Parasitárias, Rio de Janeiro, Brazil

7. Institute of Immunology and Immunotherapy, Institute of Biomedical Research College of Medical and Dental Science, Birmingham, United Kingdom

8. Department of Dermatology and Venereology, Taiyuan Central Hospital of Shanxi Medical University, Shanxi, China

9. Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA

Abstract

Cryptococcus neoformans causes cryptococcal meningitis, which is frequent in patients with HIV/AIDS, especially in less-developed countries. The incidence of cryptococcal meningitis is close to 1 million each year globally.

Funder

Major National R&D Projects of the National Health Department

National Natural Science Foundation of China

Shanghai Science and Technology Committee

Chinese Academy of Engineering

Shanghai Municipal Commission of Health and Family Planning

Shanghai Sailing Program

EMSL

NIH grants

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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