Therapeutic Potential of Intravenous Phage as Standalone Therapy for Recurrent Drug-Resistant Urinary Tract Infections

Author:

Le Tram12,Nang Sue C.3,Zhao Jinxin3,Yu Heidi H.3,Li Jian3ORCID,Gill Jason J.14,Liu Mei12,Aslam Saima56ORCID

Affiliation:

1. Center for Phage Technology, Texas A&M AgriLife Research, Texas A&M University, College Station, Texas, USA

2. Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA

3. Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia

4. Department of Animal Science, Texas A&M University, College Station, Texas, USA

5. Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California, USA

6. Center for Innovative Phage Applications and Therapeutics, University of California San Diego, La Jolla, California, USA

Abstract

Recurrent urinary tract infections (rUTI) are common in kidney transplant recipients (KTR) and are associated with multidrug resistance and increased morbidity/mortality. Novel antibiotic alternatives to reduce UTI recurrence are critically needed.

Funder

UC Chancellor's Innovation Fund

Monash-UCSD Seed Fund

DHAC | National Health and Medical Research Council

HHS | NIH | National Institute of Allergy and Infectious Diseases

Texas A and M University

Texas AgriLife Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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