A Revised Species Concept for Opportunistic Mucor Species Reveals Species-Specific Antifungal Susceptibility Profiles

Author:

Wagner Lysett1,de Hoog Sybren23,Alastruey-Izquierdo Ana4ORCID,Voigt Kerstin56,Kurzai Oliver17ORCID,Walther Grit1

Affiliation:

1. German National Reference Center for Invasive Fungal Infections, Leibniz Institute for Natural Product Research and Infection Biology—Hans Knöll Institute, Jena, Germany

2. Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands

3. Center of Expertise in Mycology of Radboud University Medical Center/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands

4. Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain

5. Jena Microbial Resource Collection, Leibniz Institute for Natural Product Research and Infection Biology—Hans Knöll Institute, Jena, Germany

6. Faculty of Biology and Pharmacy, Institute of Microbiology, Department of Microbiology and Molecular Biology, Friedrich Schiller University Jena, Jena, Germany

7. Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany

Abstract

Recently, the species concept of opportunistic Mucor circinelloides and its relatives has been revised, resulting in the recognition of its classical formae as independent species and the description of new species. In this study, we used isolates of all clinically relevant Mucor species and performed susceptibility testing using the EUCAST reference method to identify potential species-specific susceptibility patterns.

Funder

German Ministry of Health

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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