Novel Plasmid-Mediated tet (X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate-Reference-Cited by-同舟云学术

Novel Plasmid-Mediated tet (X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate

Published:2019-12-20 Issue:1 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wang Liyuan¹,Liu Dejun²,Lv Yuan¹,Cui Lanqing¹,Li Yun¹,Li Tianmeng¹,Song Huangwei²,Hao Yuxin²,Shen Jianzhong²,Wang Yang²,Walsh Timothy R.²³

Affiliation:

1. Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China

2. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China

3. Department of Medical Microbiology and Infectious Disease, Institute of Infection and Immunity, Cardiff, United Kingdom

Abstract

A novel, plasmid-mediated, high-level tigecycline resistance tet (X) gene variant, tet (X5), was detected in a clinical Acinetobacter baumannii isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. The tet (X5)-containing plasmid could only be transferred to A. baumannii via electrotransformation.

Funder

Medical Research Council grants DETER-XDRE-CHINA

National Natural Science Foundation of China

MOST | National Key Research and Development Program of China Stem Cell and Translational Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01326-19

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