Functional Properties of Oligomeric and Monomeric Forms of Helicobacter pylori VacA Toxin-Reference-Cited by-同舟云学术

Functional Properties of Oligomeric and Monomeric Forms of Helicobacter pylori VacA Toxin

Published:2021-11-16 Issue:12 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Caso Georgia C.¹,McClain Mark S.¹^ORCID,Erwin Amanda L.²,Truelock Mandy D.³,Campbell Anne M.¹,Leasure Catherine S.³,Nagel Marcus⁴,Schey Kevin L.⁴,Lacy D. Borden³⁵^ORCID,Ohi Melanie D.²,Cover Timothy L.¹³⁵^ORCID

Affiliation:

1. Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

2. Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA

3. Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

4. Mass Spectrometry Research Center, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

5. Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, USA

Abstract

Helicobacter pylori VacA is a secreted toxin that assembles into water-soluble oligomeric structures and forms anion-selective membrane channels. Acidification of purified VacA enhances its activity in cell culture assays.

Funder

HHS | National Institutes of Health

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00348-21

Reference68 articles.

1. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis

2. Helicobacter pylori in Health and Disease