Antigenic Profile of Avian H5N1 Viruses in Asia from 2002 to 2007-Reference-Cited by-全球学者库

Antigenic Profile of Avian H5N1 Viruses in Asia from 2002 to 2007

Published:2008-02-15 Issue:4 Volume:82 Page:1798-1807
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wu Wai Lan¹,Chen Yixin²³,Wang Pui¹,Song Wenjun¹,Lau Siu-Ying¹,Rayner Jane M.¹,Smith Gavin J. D.¹,Webster Robert G.⁴,Peiris J. S. Malik¹,Lin Tianwei¹³,Xia Ningshao²³,Guan Yi¹⁵,Chen Honglin¹⁵

Affiliation:

1. State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology and the Research Center of Infection and Immunology, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, People's Republic of China

2. National Institute of Diagnostics and Vaccine Development in Infectious Diseases

3. School of Life Sciences, Xiamen University, Xiamen, People's Republic of China

4. Virology Division, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105

5. International Institute of Infection and Immunity, Shantou University, Shantou, People's Republic of China

Abstract

ABSTRACT Antigenic profiles of post-2002 H5N1 viruses representing major genetic clades and various geographic sources were investigated using a panel of 17 monoclonal antibodies raised from five H5N1 strains. Four antigenic groups from seven clades of H5N1 virus were distinguished and characterized based on their cross-reactivity to the monoclonal antibodies in hemagglutination inhibition and cell-based neutralization assays. Genetic polymorphisms associated with the variation of antigenicity of H5N1 strains were identified and further verified in antigenic analysis with recombinant H5N1 viruses carrying specific mutations in the hemagglutinin protein. Modification of some of these genetic variations produced marked improvement to the immunogenicity and cross-reactivity of H5N1 strains in assays utilizing monoclonal antibodies and ferret antisera raised against clade 1 and 2 H5N1 viruses, suggesting that these sites represent antigenically significant amino acids. These results provide a comprehensive antigenic profile for H5N1 virus strains circulating in recent years and will facilitate the recognition of emerging antigenic variants of H5N1 virus and aid in the selection of vaccine strains.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02256-07

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