Haemophilus ducreyi Infection Induces Oxidative Stress, Central Metabolic Changes, and a Mixed Pro- and Anti-inflammatory Environment in the Human Host-Reference-Cited by-全球学者库

Haemophilus ducreyi Infection Induces Oxidative Stress, Central Metabolic Changes, and a Mixed Pro- and Anti-inflammatory Environment in the Human Host

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Brothwell Julie A.¹^ORCID,Fortney Kate R.¹,Gao Hongyu²,Wilson Landon S.³,Andrews Caroline F.³,Tran Tuan M.¹⁴⁵,Hu Xin⁶,Batteiger Teresa A.⁴,Barnes Stephen³⁷,Liu Yunlong²⁸,Spinola Stanley M.¹⁴⁹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA

2. Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA

3. Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama, USA

4. Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA

5. Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA

6. Division of Pulmonary, Allergy, and Critical Care, Emory University, Atlanta, Georgia, USA

7. Targeted Metabolomics and Proteomics Laboratory, University of Alabama at Birmingham, Birmingham, Alabama, USA

8. Department of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA

9. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA

Abstract

Interactions between the host and bacteria at sites of infection in humans are poorly understood. We inoculated human volunteers on the upper arm with the skin pathogen H. ducreyi or a buffer control and biopsied the resulting infected and sham-inoculated sites.

Funder

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03125-22

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