Comparative Genomics of Borderline Oxacillin-Resistant Staphylococcus aureus Detected during a Pseudo-outbreak of Methicillin-Resistant S. aureus in a Neonatal Intensive Care Unit-Reference-Cited by-同舟云学术

Comparative Genomics of Borderline Oxacillin-Resistant Staphylococcus aureus Detected during a Pseudo-outbreak of Methicillin-Resistant S. aureus in a Neonatal Intensive Care Unit

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Sawhney Sanjam S.¹^ORCID,Ransom Eric M.²,Wallace Meghan A.²,Reich Patrick J.³,Dantas Gautam¹²⁴⁵^ORCID,Burnham Carey-Ann D.²³⁴^ORCID

Affiliation:

1. The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA

2. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

3. Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA

4. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

5. Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA

Abstract

In this study, we found a high prevalence of Staphylococcus aureus isolates exhibiting a borderline oxacillin resistance phenotype (BORSA) in our neonatal intensive care unit (NICU) serendipitously due to the type of MRSA screening agar used by our laboratory for active surveillance cultures. Subsequent phenotypic and molecular characterization highlighted an unexpected prevalence and variability of BORSA isolates.

Funder

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03196-21

Reference82 articles.

1. Vital Signs:Epidemiology and Recent Trends in Methicillin-Resistant and in Methicillin-SusceptibleStaphylococcus aureusBloodstream Infections — United States

2. Anonymous. 2021. Multidrug-resistant organism & Clostridioides difficile infection (MDRO/CDI) module on Center for Diseases Control and Prevention. National Healthcare Safety Network CDC Atlanta GA. https://www.cdc.gov/nhsn/pdfs/pscmanual/12pscmdro_cdadcurrent.pdf. Accessed 21 May 2021.

3. The emergence of mecC methicillin-resistant Staphylococcus aureus

4. An Outbreak of Borderline Oxacillin-ResistantStaphylococcus aureus(BORSA) in a Dermatological Unit

5. Failure of Cloxacillin in Treatment of a Patient with Borderline Oxacillin-Resistant Staphylococcus aureus Endocarditis

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