Influenza Virus NS1 Protein Counteracts PKR-Mediated Inhibition of Replication-Reference-Cited by-同舟云学术

Influenza Virus NS1 Protein Counteracts PKR-Mediated Inhibition of Replication

Published:2000-07 Issue:13 Volume:74 Page:6203-6206
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Bergmann Michael¹,Garcia-Sastre Adolfo²,Carnero Elena²,Pehamberger Hubert³,Wolff Klaus³,Palese Peter²,Muster Thomas³

Affiliation:

1. Department of Surgery1and

2. Department of Microbiology, Mount Sinai Medical Center, New York, New York 100292

3. Department of Dermatology,3University of Vienna Medical School, 1090 Vienna, Austria, and

Abstract

ABSTRACT The availability of an influenza virus NS1 gene knockout virus (delNS1 virus) allowed us to establish the significance of the biological relationship between the influenza virus NS1 protein and double-stranded-RNA-activated protein kinase (PKR) in the life cycle and pathogenicity of influenza virus. Our results show that the lack of functional PKR permits the delNS1 virus to replicate in otherwise nonpermissive hosts, suggesting that the major function of the influenza virus NS1 protein is to counteract or prevent the PKR-mediated antiviral response.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.13.6203-6206.2000

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