Transfer of Specificity for Human Immunodeficiency Virus Type 1 into Primary Human T Lymphocytes by Introduction of T-Cell Receptor Genes-Reference-Cited by-同舟云学术

Transfer of Specificity for Human Immunodeficiency Virus Type 1 into Primary Human T Lymphocytes by Introduction of T-Cell Receptor Genes

Published:2000-09 Issue:17 Volume:74 Page:8207-8212
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Cooper Laurence J. N.¹²,Kalos Michael¹,Lewinsohn Deborah A.¹,Riddell Stanley R.¹³,Greenberg Philip D.¹³

Affiliation:

1. Program in Immunology, Fred Hutchinson Cancer Research Center,1 and

2. Department of Pediatric Hematology and Oncology2 and

3. Departments of Immunology and Medicine,3University of Washington, Seattle, Washington

Abstract

ABSTRACT The introduction of genes encoding T-cell receptor (TCR) chains specific for human immunodeficiency virus into T cells of infected patients represents a means to quantitatively and qualitatively improve immunity to the virus. Our results demonstrate that the high level of TCR expression required for physiologic functioning can be reproducibly achieved with retroviral vectors encoding full-length unmodified TCR chains under the control of a strong internal constitutive phosphoglycerate kinase promoter.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.17.8207-8212.2000

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