Quantitation of Latent Varicella-Zoster Virus and Herpes Simplex Virus Genomes in Human Trigeminal Ganglia-Reference-Cited by-同舟云学术

Quantitation of Latent Varicella-Zoster Virus and Herpes Simplex Virus Genomes in Human Trigeminal Ganglia

Published:1999-12 Issue:12 Volume:73 Page:10514-10518
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Pevenstein Stephanie R.¹,Williams Richard K.¹,McChesney Daniel¹,Mont Erik K.²,Smialek John E.³,Straus Stephen E.¹

Affiliation:

1. Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases,1 and

2. Anatomical Pathology Service, Laboratory of Pathology, National Cancer Institute,2 National Institutes of Health, Bethesda, and

3. Department of Pathology, University of Maryland School of Medicine, Baltimore,3 Maryland

Abstract

ABSTRACT Using real-time fluorescence PCR, we quantitated the numbers of copies of latent varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) genomes in 15 human trigeminal ganglia. Eight (53%) and 1 (7%) of 15 ganglia were PCR positive for HSV-1 or -2 glycoprotein G genes, with means of 2,902 ± 1,082 (standard error of the mean) or 109 genomes/10 5 cells, respectively. Eleven of 14 (79%) to 13 of 15 (87%) of the ganglia were PCR positive for VZV gene 29, 31, or 62. Pooling of the results for the three VZV genes yielded a mean of 258 ± 38 genomes/10 5 ganglion cells. These levels of latent viral genome loads have implications for virus distribution in and reactivation from human sensory ganglia.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.12.10514-10518.1999

Reference36 articles.

1. Varicella-zoster virus;Arvin A. M.;Fields virology,1996

2. Neuronal and lymphocytic populations in human trigeminal ganglia: implications for aging and for latent virus;Ball M. J.;Neuropathol. Appl. Neurobiol.,1982

3. Genome amplification of human papillomavirus types 16 and 18 in cervical carcinomas is related to the retention of E1/E2 genes;Berumen J.;Int. J. Cancer,1994

4. Detection of multiple human papillomavirus types in condylomata acuminata from immunosuppressed patients;Brown D. R.;J. Infect. Dis.,1994

5. Characterization of herpes simplex virus type 2 latency-associated transcription in human sacral ganglia and in cell culture;Croen K. D.;J. Infect. Dis.,1991

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