Modeling Aβ42 Accumulation in Response to Herpes Simplex Virus 1 Infection: Two Dimensional or Three Dimensional?-Reference-Cited by-同舟云学术

Modeling Aβ42 Accumulation in Response to Herpes Simplex Virus 1 Infection: Two Dimensional or Three Dimensional?

Published:2021-02-10 Issue:5 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Abrahamson Eric E.¹²,Zheng Wenxiao³⁴,Muralidaran Vaishali⁴,Ikonomovic Milos D.¹²⁴,Bloom David C.⁵,Nimgaonkar Vishwajit L.⁴⁶,D’Aiuto Leonardo⁴⁶^ORCID

Affiliation:

1. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

2. Geriatric Research Education and Clinical Center, Pittsburgh VA Healthcare System, Pittsburgh, Pennsylvania, USA

3. Department of Psychiatry, The Second Xiangya Hospital, Xiangya School of Medicine, Central South University, Changsha, China

4. Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

5. Department of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA

6. VISN 4 MIRECC, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA

Abstract

The pathogen hypothesis of Alzheimer’s disease (AD) proposes that brain HSV-1 infection is an initial source of amyloid beta (Aβ) peptide-containing amyloid plaque development. Aβ accumulation was reported in HSV-1-infected 2D neuronal cultures and neural stem cell cultures as well as in HSV-1-infected 3D neuronal culture models.

Funder

U.S. Department of Veterans Affairs

HHS | NIH | National Institute of Neurological Disorders and Stroke

Stanley Medical Research Institute

HHS | NIH | National Institute on Aging

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02219-20

Reference29 articles.