Molecular Identification of Aspergillus Species Collected for the Transplant-Associated Infection Surveillance Network

Author:

Balajee S. Arunmozhi1,Kano Rui1,Baddley John W.23,Moser Stephen A.4,Marr Kieren A.56,Alexander Barbara D.7,Andes David8,Kontoyiannis Dimitrios P.9,Perrone Giancarlo10,Peterson Stephen11,Brandt Mary E.1,Pappas Peter G.2,Chiller Tom1

Affiliation:

1. Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia

2. Department of Medicine

3. Department of Medicine, Birmingham Veterans Affairs Medical Center, Birmingham, Alabama

4. Department of Pathology, University of Alabama at Birmingham

5. Fred Hutchinson Cancer Research Center, Seattle, Washington

6. Johns Hopkins University, Baltimore, Maryland

7. Duke University, Durham, North Carolina

8. University of Wisconsin, Madison, Wisconsin

9. M. D. Anderson Cancer Center, Houston, Texas

10. Institute of Sciences of Food Production, National Research Council, Bari, Italy

11. National Center for Agricultural Utilization Research, U.S. Department of Agriculture, Peoria, Illinois

Abstract

ABSTRACT A large aggregate collection of clinical isolates of aspergilli ( n = 218) from transplant patients with proven or probable invasive aspergillosis was available from the Transplant-Associated Infection Surveillance Network, a 6-year prospective surveillance study. To determine the Aspergillus species distribution in this collection, isolates were subjected to comparative sequence analyses by use of the internal transcribed spacer and β-tubulin regions. Aspergillus fumigatus was the predominant species recovered, followed by A. flavus and A. niger . Several newly described species were identified, including A. lentulus and A. calidoustus ; both species had high in vitro MICs to multiple antifungal drugs. Aspergillus tubingensis , a member of the A. niger species complex, is described from clinical specimens; all A. tubingensis isolates had low in vitro MICs to antifungal drugs.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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