Neisseria cinerea with High Ceftriaxone MIC Is a Source of Ceftriaxone and Cefixime Resistance-Mediating penA Sequences in Neisseria gonorrhoeae-Reference-Cited by-同舟云学术

Neisseria cinerea with High Ceftriaxone MIC Is a Source of Ceftriaxone and Cefixime Resistance-Mediating penA Sequences in Neisseria gonorrhoeae

Published:2018-03 Issue:3 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Igawa Gene¹,Yamagishi Yuka²,Lee Ken-Ichi¹^ORCID,Dorin Misato¹,Shimuta Ken¹,Suematsu Hiroyuki²,Nakayama Shu-Ichi¹,Mikamo Hiroshige²,Unemo Magnus³,Ohnishi Makoto¹⁴

Affiliation:

1. Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan

2. Department of Clinical Infectious Diseases, Aichi Medical University, Aichi, Japan

3. WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden

4. Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan

Abstract

ABSTRACT Mosaic penA alleles have caused most of the cephalosporin resistance in Neisseria gonorrhoeae , but their evolution is mostly unknown. The penA gene from Neisseria cinerea strain AM1601 (ceftriaxone MIC, 1.0 μg/ml) caused ceftriaxone resistance (MIC, 1 μg/ml) in a ceftriaxone-susceptible gonococcal strain. The 3′-terminal half of AM1601 penA was almost identical to that of the ceftriaxone-resistant gonococcal GU140106 and FC428 strains. N. cinerea can serve as a reservoir of ceftriaxone resistance-mediating penA sequences that can be transferred to gonococci.

Funder

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02069-17

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