Novel Multilocus Sequence Typing and Global Sequence Clustering Schemes for Characterizing the Population Diversity of Streptococcus mitis

Author:

Kalizang’oma Akuzike12ORCID,Kwambana-Adams Brenda12,Chan Jia Mun1,Viswanath Aishwarya3,Gori Andrea1ORCID,Richard Damien4,Jolley Keith A.5,Lees John6,Goldblatt David7,Beleza Sandra8,Bentley Stephen D.9,Heyderman Robert S.1,Chaguza Chrispin19101112

Affiliation:

1. NIHR Mucosal Pathogens Research Unit, Division of Infection and Immunity, University College London, London, United Kingdom

2. Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi

3. UCL Division of Medicine, University College London, London, United Kingdom

4. UCL Genetics Institute, University College London, London, United Kingdom

5. Department of Zoology, University of Oxford, Oxford, United Kingdom

6. Pathogen Informatics and Modelling, European Bioinformatics Institute, Hinxton, United Kingdom

7. University College London, Great Ormond Street Institute of Child Health, London, United Kingdom

8. University of Leicester, Department of Genetics and Genome Biology, Leicester, United Kingdom

9. Parasites and Microbes, Wellcome Sanger Institute, Hinxton, United Kingdom

10. Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut, USA

11. Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, United Kingdom

12. Yale Institute for Global Health, Yale University, New Haven, Connecticut, USA

Abstract

Streptococcus mitis is a common oral commensal and an opportunistic pathogen that causes bacteremia and infective endocarditis; however, the species has received little attention compared to other pathogenic streptococcal species. Effective and easy-to-use molecular typing tools are essential for understanding bacterial population diversity and biology, but schemes specific for S. mitis are not currently available.

Funder

National Institute for Health and Care Research

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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