Cell-Intrinsic CD38 Expression Sustains Exhausted CD8 + T Cells by Regulating Their Survival and Metabolism during Chronic Viral Infection
Author:
Affiliation:
1. Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California Irvine, Irvine, California, USA
2. Center for Virus Research, University of California Irvine, Irvine, California, USA
Abstract
Funder
HHS | National Institutes of Health
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Link
https://journals.asm.org/doi/pdf/10.1128/jvi.00225-23
Reference57 articles.
1. Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology
2. Antigen-induced clustering of surface CD38 and recruitment of intracellular CD38 to the immunologic synapse
3. CD38: T Cell Immuno-Metabolic Modulator
4. NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus
5. ADP-ribosyl Cyclase and CD38 Catalyze the Synthesis of a Calcium-mobilizing Metabolite from NADP+
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1. Inhibition of CD38 enzymatic activity enhances CAR-T cell immune-therapeutic efficacy by repressing glycolytic metabolism;Cell Reports Medicine;2024-02
2. CD8 T-cell dysfunction is linked with CAR T-cell failure and can be mitigated by a non-alpha IL-2 agonist, pegenzileukin;2023-08-29
3. Cytomegalovirus and Epstein–Barr virus co-infected young and middle-aged adults can have an aging-related T-cell phenotype;Scientific Reports;2023-07-05
4. CD38 marks the exhausted CD8+ tissue-resident memory T cells in hepatocellular carcinoma;Frontiers in Immunology;2023-06-12
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