Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons-Reference-Cited by-同舟云学术

Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Kong Weili¹²,Montano Mauricio¹²,Corley Michael J.³,Helmy Ekram¹²,Kobayashi Hirofumi⁴,Kinisu Martin¹²,Suryawanshi Rahul²,Luo Xiaoyu¹²,Royer Loic A.⁴,Roan Nadia R.¹²⁵,Ott Melanie¹²⁶⁷,Ndhlovu Lishomwa C.³,Greene Warner C.¹²⁶⁷^ORCID

Affiliation:

1. Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, California, USA

2. Gladstone Institute of Virology, San Francisco, California, USA

3. Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York, USA

4. CZ Biohub, San Francisco, California, USA

5. Department of Urology, University of California, San Francisco, San Francisco, California, USA

6. Department of Medicine, University of California, San Francisco, San Francisco, California, USA

7. Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA

Abstract

SARS-CoV-2 infection primarily targets the lung but may also damage other organs, including the brain, heart, kidney, and intestine. Central nervous system (CNS) pathologies include loss of smell and taste, headache, delirium, acute psychosis, seizures, and stroke.

Funder

UCSF-Gladstone for AIDS Research

Van Auken Private Foundation

David Henke, Pamela and Edward Taft

Fast Grants

HHS | NIH | National Institute on Drug Abuse

James B. Pendleton Charitable Trust

Roddenberry Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology