A Highly Substituted Ring-Fused 2-Pyridone Compound Targeting PrfA and the Efflux Regulator BrtA in Listeria monocytogenes-Reference-Cited by-同舟云学术

A Highly Substituted Ring-Fused 2-Pyridone Compound Targeting PrfA and the Efflux Regulator BrtA in Listeria monocytogenes

Published:2023-06-27 Issue:3 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Tükenmez Hasan¹²³⁴⁵^ORCID,Singh Pardeep¹,Sarkar Souvik¹²,Çakır Melike⁴,Oliveira Ana H.²³⁴,Lindgren Cecilia¹,Vaitkevicius Karolis²³⁴,Bonde Mari⁵,Sauer-Eriksson A. Elisabeth¹²,Almqvist Fredrik¹²,Johansson Jörgen²³⁴^ORCID

Affiliation:

1. Department of Chemistry, Umeå University, Umeå, Sweden

2. Umeå Centre of Microbial Research (UCMR), Umeå University, Umeå, Sweden

3. Molecular Infection Medicine, Sweden (MIMS), Umeå University, Umeå, Sweden

4. Department of Molecular Biology, Umeå University, Umeå, Sweden

5. QureTech Bio, Umeå, Sweden

Abstract

Bacteria resistant to one or several antibiotics are a very large problem, threatening not only treatment of infections but also surgery and cancer treatments. Thus, new types of antibacterial drugs are desperately needed.

Funder

Familjen Erling-Perssons Stiftelse

HHS | National Institutes of Health

Stiftelsen Olle Engkvist Byggmästare

VINNOVA

Vetenskapsrådet

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00449-23