Rothia from the Human Nose Inhibit Moraxella catarrhalis Colonization with a Secreted Peptidoglycan Endopeptidase

Author:

Stubbendieck Reed M.12ORCID,Dissanayake Eishika3,Burnham Peter M.1,Zelasko Susan E.14,Temkin Mia I.1,Wisdorf Sydney S.3,Vrtis Rose F.3,Gern James E.35ORCID,Currie Cameron R.16ORCID

Affiliation:

1. Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA

2. Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, Oklahoma, USA

3. Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

4. Microbiology Doctoral Training Program, University of Wisconsin-Madison, Madison, Wisconsin, USA

5. Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

6. David Braley Centre for Antibiotic Discovery, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

Abstract

Moraxella catarrhalis is a pathobiont of the respiratory tract, responsible for ear infections in children and wheezing illnesses in children and adults with chronic respiratory diseases. Detection of M. catarrhalis during wheezing episodes in early life is associated with the development of persistent asthma.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | NIH | U.S. National Library of Medicine

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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