Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation-Reference-Cited by-同舟云学术

Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation

Published:2017-01-19 Issue:3 Volume:5 Page:
ISSN:2169-8287
Container-title:Genome Announcements
language:en
Short-container-title:Genome Announc

Author:

Corcoran Kathleen¹,Sherrod Carly J.¹,Perkowski Ellen F.¹,Texier Jordan¹,Li Fengsheng²,Wang I-Ming²,McVoy Michael³,Fu Tong-Ming²^ORCID,Dittmer Dirk P.¹

Affiliation:

1. Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center Program in Global Oncology, Center for AIDS Research (CfAR), School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

2. MRL, Merck & Co., Inc., Kenilworth, New Jersey, USA

3. Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA

Abstract

ABSTRACT Cytomegalovirus displays genetic heterogeneity, which has implications for antiviral and vaccine development. Many studies have focused on laboratory isolates that have been extensively adapted for growth on fibroblasts. Here, we report whole-genome sequences for 10 human cytomegalovirus (HCMV) strains that readily grow on ARPE-19 human retinal pigment epithelial cells.

Funder

HHS | U.S. Public Health Service

Publisher

American Society for Microbiology

Subject

Genetics,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/genomeA.01433-16

Reference10 articles.

1. Limits and patterns of cytomegalovirus genomic diversity in humans

2. Sequences of complete human cytomegalovirus genomes from infected cell cultures and clinical specimens

3. Coding potential of laboratory and clinical strains of human cytomegalovirus