In Vitro Activity of Terbinafine Combined with Caspofungin and Azoles against Pythium insidiosum-Reference-Cited by-同舟云学术

In Vitro Activity of Terbinafine Combined with Caspofungin and Azoles against Pythium insidiosum

Published:2009-05 Issue:5 Volume:53 Page:2136-2138
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cavalheiro Ayrton S.¹²,Maboni Grazieli²,de Azevedo Maria I.²,Argenta Juliana S.²,Pereira Daniela I. B.²,Spader Tatiana B.³²,Alves Sydney H.¹³²,Santurio Janio M.¹²

Affiliation:

1. Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil

2. Laboratório de Pesquisas Micológicas (LAPEMI), Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil

3. Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil

Abstract

ABSTRACT In this text we evaluated the in vitro antifungal activities of terbinafine combined with caspofungin, miconazole, ketoconazole, and fluconazole against 17 Pythium insidiosum strains by using the microdilution checkerboard method. Synergistic interactions were observed with terbinafine combined with caspofungin (41.2% of the strains), fluconazole (41.2%), ketoconazole (29.4%), and miconazole (11.8%). No antagonistic effects were observed. The combination of terbinafine plus caspofungin or terbinafine plus fluconazole may have significant therapeutic potential for treatment of pythiosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01506-08

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