The Impact of Evolving SARS-CoV-2 Mutations and Variants on COVID-19 Vaccines-Reference-Cited by-同舟云学术

The Impact of Evolving SARS-CoV-2 Mutations and Variants on COVID-19 Vaccines

Published:2022-04-26 Issue:2 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

McLean Gary¹^ORCID,Kamil Jeremy²^ORCID,Lee Benhur³^ORCID,Moore Penny⁴⁵^ORCID,Schulz Thomas F.⁶⁷⁸^ORCID,Muik Alexander⁹^ORCID,Sahin Ugur⁹^ORCID,Türeci Özlem⁹,Pather Shanti⁹^ORCID

Affiliation:

1. School of Human Sciences, London Metropolitan University and National Heart and Lung Institute, Imperial College London, London, United Kingdom

2. Louisiana State University Health, Shreveport, Louisiana, USA

3. Icahn School of Medicine at Mount Sinai, New York, New York, USA

4. Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa

5. MRC Antibody Immunity Research Unit, School of Pathology, The University of the Witwatersrand, Johannesburg, South Africa

6. Institute of Virology, Hannover Medical School, Hannover, Germany

7. Cluster of Excellence 2155 RESIST, Hannover, Germany

8. German Centre for Infection Research, Hannover-Braunschweig Site, Germany

9. BioNTech, Mainz, Germany

Abstract

The emergence of several new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in recent months has raised concerns around the potential impact on ongoing vaccination programs. Data from clinical trials and real-world evidence suggest that current vaccines remain highly effective against the alpha variant (B.1.1.7), while some vaccines have reduced efficacy and effectiveness against symptomatic disease caused by the beta variant (B.1.351) and the delta variant (B.1.617.2); however, effectiveness against severe disease and hospitalization caused by delta remains high.

Funder

BioNtech

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02979-21

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