Coinfection with SARS-CoV-2 and Influenza A Virus Increases Disease Severity and Impairs Neutralizing Antibody and CD4 + T Cell Responses

Author:

Kim Eun-Ha1,Nguyen Thi-Quyen12,Casel Mark Anthony B.1,Rollon Rare1,Kim Se-Mi3,Kim Young-Il3,Yu Kwang-Min1,Jang Seung-Gyu13,Yang Jihyun4,Poo Haryoung4,Jung Jae U.5ORCID,Choi Young Ki13ORCID

Affiliation:

1. College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea

2. Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, Vietnam

3. Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea

4. Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, Daejeon, Republic of Korea

5. Department of Cancer Biology and Global Center for Pathogens Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

Abstract

The cocirculation of influenza virus merging with the COVID-19 pandemic raises a potentially severe threat to public health. Recently, increasing numbers of SARS-CoV-2 and influenza virus coinfection have been reported from many countries.

Funder

Institute for Basic Science

Korea Research Institute of Bioscience and Biotechnology

MOHW | Korea National Institute of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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