SARS-CoV-2 nsp13 Restricts Episomal DNA Transcription without Affecting Chromosomal DNA-Reference-Cited by-全球学者库

SARS-CoV-2 nsp13 Restricts Episomal DNA Transcription without Affecting Chromosomal DNA

Published:2023-07-27 Issue:7 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Li Aixin¹²,Zhang Bei¹,Zhao Kaitao¹^ORCID,Yin Zhinang³,Teng Yan¹,Zhang Lu¹,Xu Zaichao¹,Liang Kaiwei³,Cheng Xiaoming¹⁴⁵,Xia Yuchen¹^ORCID

Affiliation:

1. State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Hubei Jiangxia Laboratory, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China

2. School of Medical Laboratory, Weifang Medical University, Weifang, China

3. Department of Pathophysiology, TaiKang Medical School, Wuhan University, Wuhan, China

4. Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China

5. Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China

Abstract

To combat COVID-19, we need to understand SARS-CoV-2 and develop effective antiviral drugs. In our study, we serendipitously found that SARS-CoV-2 nsp13 could suppress episomal DNA transcription without affecting chromosomal DNA.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00512-23

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