Interleukin-27 Promotes Divergent Effects on HIV-1 Infection in Peripheral Blood Mononuclear Cells through BST-2/Tetherin-Reference-Cited by-同舟云学术

Interleukin-27 Promotes Divergent Effects on HIV-1 Infection in Peripheral Blood Mononuclear Cells through BST-2/Tetherin

Published:2023-01-31 Issue:1 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Temerozo Jairo R.¹²^ORCID,Ferreira Pedro L. C.¹,Linhares-Lacerda Leandra³²,Vieira Rhaíssa C.¹,Cister-Alves Bruno¹,Gobbo Livia¹,Ribeiro-Alves Marcelo⁴²,Menna-Barreto Rubem F. S.⁵^ORCID,Bou-Habib Dumith Chequer¹²^ORCID

Affiliation:

1. Laboratory on Thymus Research, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil

2. National Institute of Science and Technology on Neuroimmunomodulation, Rio de Janeiro, Brazil

3. Laboratory of Immunobiology of Leishmaniasis, Department of Immunology, Paulo de Goes Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

4. HIV/AIDS Clinical Research Center, Evandro Chagas National Institute of Infectology, Fiocruz, Rio de Janeiro, Brazil

5. Laboratory of Cellular Biology, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil

Abstract

Here, we describe new findings related to the ability of the cytokine IL-27 to regulate the growth of HIV-1 in CD4 + T lymphocytes. IL-27 has long been considered a potent inhibitor of HIV-1 replication, a notion based on several reports showing that this cytokine controls HIV-1 infection in peripheral blood mononuclear cells (PBMCs), monocyte-derived macrophages, and dendritic cells.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Mercosur Structural Convergence Fund

Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01752-22

Reference64 articles.

1. IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells

2. WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27

3. Understanding the Pro- and Anti-Inflammatory Properties of IL-27

4. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

5. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10