Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori-Reference-Cited by-同舟云学术

Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori

Published:1996-02 Issue:2 Volume:40 Page:477-480
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Versalovic J¹,Shortridge D¹,Kibler K¹,Griffy M V¹,Beyer J¹,Flamm R K¹,Tanaka S K¹,Graham D Y¹,Go M F¹

Affiliation:

1. Division of Digestive Diseases, Baylor College of Medicine, Houston, Texas, USA. jamesv@bcm.tmc.edu

Abstract

Twelve clarithromycin-resistant Helicobacter pylori isolates (100% of resistant isolates examined) from seven different patients each contained an A-->G transition mutation within a conserved loop of 23S rRNA. A-->G transition mutations at positions cognate with Escherichia coli 23S rRNA positions 2058 and 2059 were identified. Clarithromycin-susceptible H. pylori isolates from 14 different patients displayed no polymorphisms in a conserved loop within domain V of 23S rRNA. The study is the first to report mutations in H. pylori associated with resistance to an antimicrobial agent used in established peptic ulcer treatment regimens.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.40.2.477

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