Robustness of the Ferret Model for Influenza Risk Assessment Studies: a Cross-Laboratory Exercise

Author:

Belser Jessica A.1,Lau Eric H. Y.2,Barclay Wendy3ORCID,Barr Ian G.4,Chen Hualan5,Fouchier Ron A. M.6,Hatta Masato7,Herfst Sander6ORCID,Kawaoka Yoshihiro7ORCID,Lakdawala Seema S.8,Lee Leo Yi Yang4,Neumann Gabriele7,Peiris Malik2ORCID,Perez Daniel R.9ORCID,Russell Charles10ORCID,Subbarao Kanta411,Sutton Troy C.12ORCID,Webby Richard J.10,Yang Huanliang5,Yen Hui-Ling2ORCID,Blanchard Elisabeth,Maines Taronna R.,Choy Ka-Tim,Sia Sin Fun,Su Wen,Frise Rebecca,Zhou Jie,Hurt Aeron C.,Li Chengjun,Bestebroer Theo,de Meulder Dennis,Lexmond Pascal,Chiba Shiho,Bhagwat Amar,Jones Jennifer E.,Kormuth Karen A.,Le Sage Valarie,Caceres C. Joaquin,Carnaccini Silvia,Ferreri Lucas M.,Geiger Ginger,DeBeauchamp Jennifer L.,Hu Meng,Jeevan Trushar,Kercher Lisa A.,Patel Devanshi R.,Septer Kayla M.,Sim Derek G.,

Affiliation:

1. Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

3. Imperial College, London, United Kingdom

4. WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Doherty Institute, Melbourne, Australia

5. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

6. Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands

7. University of Wisconsin, Madison, Wisconsin, USA

8. University of Pittsburgh, Pittsburgh, Pennsylvania, USA

9. University of Georgia, Athens, Georgia, USA

10. Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

11. Department of Microbiology and Immunology, University of Melbourne, Doherty Institute, Melbourne, Australia

12. Pennsylvania State University, University Park, Pennsylvania, USA

Abstract

Following detection of a novel virus, rapid characterization efforts (both in vitro and in vivo ) are undertaken at numerous laboratories worldwide to evaluate the relative risk posed to human health. Aggregation of these data are critical, but the use of nonstandardized protocols can make interpretation of divergent results a challenge.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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