Computer automated structure evaluation of quinolone antibacterial agents-Reference-Cited by-同舟云学术

Computer automated structure evaluation of quinolone antibacterial agents

Published:1987-11 Issue:11 Volume:31 Page:1831-1840
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Klopman G¹,Macina O T¹,Levinson M E¹,Rosenkranz H S¹

Affiliation:

1. Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106.

Abstract

The Computer Automated Structure Evaluation (CASE) program was used to study a series of quinolone antibacterial agents for which experimental data pertaining to DNA gyrase inhibition as well as MICs against several strains of gram-positive and gram-negative bacteria are available. The result of the analysis was the automatic generation of molecular fragments relevant to the respective biological endpoints. The potential significance of these major activating-inactivating fragments to the biological activity is discussed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.31.11.1831

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