Ultrastructural Localization of the Herpes Simplex Virus Type 1 U L 31, U L 34, and U S 3 Proteins Suggests Specific Roles in Primary Envelopment and Egress of Nucleocapsids-Reference-Cited by-同舟云学术

Ultrastructural Localization of the Herpes Simplex Virus Type 1 U L 31, U L 34, and U S 3 Proteins Suggests Specific Roles in Primary Envelopment and Egress of Nucleocapsids

Published:2002-09 Issue:17 Volume:76 Page:8939-8952
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Reynolds Ashley E.¹,Wills Elizabeth G.¹,Roller Richard J.²,Ryckman Brent J.²,Baines Joel D.¹

Affiliation:

1. Department of Microbiology and Immunology, Cornell University, Ithaca, New York 14853

2. Department of Microbiology, University of Iowa, Iowa City, Iowa 52242

Abstract

ABSTRACT The wild-type U L 31, U L 34, and U S 3 proteins localized on nuclear membranes and perinuclear virions; the U S 3 protein was also on cytoplasmic membranes and extranuclear virions. The U L 31 and U L 34 proteins were not detected in extracellular virions. U S 3 deletion caused (i) virion accumulation in nuclear membrane invaginations, (ii) delayed virus production onset, and (iii) reduced peak virus titers. These data support the herpes simplex virus type 1 deenvelopment-reenvelopment model of virion egress and suggest that the U S 3 protein plays an important, but nonessential, role in the egress pathway.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.76.17.8939-8952.2002

Reference51 articles.

1. The UL11 gene of herpes simplex virus 1 encodes a function that facilitates nucleocapsid envelopment and egress from cells

2. Blaho, J., C. Mitchell, and B. Roizman. 1994. An amino acid sequence shared by the herpes simplex virus 1 alpha regulatory proteins 0, 4, 22, and 27 predicts the nucleotidylylation of the UL21, UL31, UL47, and UL49 gene products. J. Biol. Chem. 269 : 17401-17410.

3. An endoplasmic reticulum-retained herpes simplex virus glycoprotein H is absent from secreted virions: evidence for reenvelopment during egress

4. The product of the UL31 gene of herpes simplex virus 1 is a nuclear phosphoprotein which partitions with the nuclear matrix

5. The null mutant of the U(L)31 gene of herpes simplex virus 1: construction and phenotype in infected cells

Cited by 292 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Extragenic suppression of an HSV-1 UL34 nuclear egress mutant reveals role for pUS9 as an inhibitor of epithelial cell-to-cell spread;Journal of Virology;2023-10-31

2. Comprehensive Analysis of the Tegument Proteins Involved in Capsid Transport and Virion Morphogenesis of Alpha, Beta and Gamma Herpesviruses;Viruses;2023-10-06

3. The Knowns and Unknowns of Herpesvirus Nuclear Egress;Annual Review of Virology;2023-09-29

4. Mechanism of herpesvirus UL24 protein regulating viral immune escape and virulence;Frontiers in Microbiology;2023-09-22

5. NECing goes: flexibility of the herpesvirus nuclear egress complex;2023-07-07