Performance of Zika Assays in the Context of Toxoplasma gondii, Parvovirus B19, Rubella Virus, and Cytomegalovirus (TORCH) Diagnostic Assays

Author:

Voordouw Bettie12,Rockx Barry1,Jaenisch Thomas3,Fraaij Pieter1,Mayaud Philippe4,Vossen Ann5,Koopmans Marion1

Affiliation:

1. Erasmus Medical Centre, Department of Viroscience, Rotterdam, The Netherlands

2. State Institute of Public Health and Environment, Department of Infectious Disease Diagnostics, Research, and Laboratory Surveillance, Bilthoven, The Netherlands

3. Heidelberg University Hospital, Department for Infectious Diseases, Heidelberg, Germany

4. London School of Hygiene and Tropical Medicine, Department of Clinical Research, London, United Kingdom

5. Leiden University Medical Centre, Department of Medical Microbiology, Leiden, The Netherlands

Abstract

Infections during pregnancy that may cause congenital abnormalities have been recognized for decades, but their diagnosis is challenging. This was again illustrated with the emergence of Zika virus (ZIKV), highlighting the inherent difficulties in estimating the extent of pre- and postnatal ZIKV complications because of the difficulties in establishing definitive diagnoses.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

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