Early Impairment of Gut Function and Gut Flora Supporting a Role for Alteration of Gastrointestinal Mucosa in Human Immunodeficiency Virus Pathogenesis-Reference-Cited by-同舟云学术

Early Impairment of Gut Function and Gut Flora Supporting a Role for Alteration of Gastrointestinal Mucosa in Human Immunodeficiency Virus Pathogenesis

Published:2008-02 Issue:2 Volume:46 Page:757-758
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Gori Andrea¹²,Tincati Camilla²,Rizzardini Giuliano³,Torti Carlo⁴,Quirino Tiziana⁵,Haarman Monique⁶,Ben Amor Kaouther⁶,van Schaik Jacqueline⁶,Vriesema Aldwin⁶,Knol Jan⁶,Marchetti Giulia⁷,Welling Gjalt⁸,Clerici Mario⁹

Affiliation:

1. Division of Infectious Diseases, Department of Internal Medicine, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy

2. Department of Internal Medicine, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy

3. 1st Division of Infectious Diseases, Luigi Sacco Hospital, Milan, Italy

4. Clinic of Infectious Diseases, University of Brescia, Brescia, Italy

5. Infectious Diseases Unit, Busto Arsizio Hospital, Busto Arsizio, Italy

6. Numico Research BV, Wageningen, The Netherlands

7. Department of Clinical Science, Luigi Sacco Hospital, University of Milan, Milan, Italy

8. Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

9. Department of Science Technology Biomedicine, University of Milan, Milan, Italy

Abstract

ABSTRACT Our results show that impairment of the gastrointestinal tracts in human immunodeficiency virus (HIV)-positive patients is present in the early phases of HIV disease. This impairment is associated with alterations in gut microbiota and intestinal inflammatory parameters. These findings support the hypothesis that alterations at the gastrointestinal-tract level are a key factor in HIV pathogenesis.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01729-07

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