Killing Two Birds with One Stone: Discovery of Dual Inhibitors of Oxygen and Fumarate Respiration in Zoonotic Parasite, Echinococcus multilocularis-Reference-Cited by-同舟云学术

Killing Two Birds with One Stone: Discovery of Dual Inhibitors of Oxygen and Fumarate Respiration in Zoonotic Parasite, Echinococcus multilocularis

Published:2023-02-22 Issue: Volume: Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Enkai Shigehiro¹²^ORCID,Kouguchi Hirokazu³,Inaoka Daniel Ken²⁴⁵^ORCID,Shiba Tomoo⁶,Hidaka Masahito³,Matsuyama Hiroyuki³,Sakura Takaya²⁴,Yagi Kinpei³⁷,Kita Kiyoshi²⁵⁸

Affiliation:

1. Department of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan

2. School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan

3. Department of Infectious Diseases, Hokkaido Institute of Public Health, Sapporo, Hokkaido, Japan

4. Department of Molecular Infection Dynamics, Shionogi Global Infectious Diseases Division, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan

5. Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

6. Department of Applied Biology, Graduate School of Science Technology, Kyoto Institute of Technology, Kyoto, Japan

7. Laboratory of Parasitology, Department of Disease Control Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

8. Department of Host-Defense Biochemistry, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan

Abstract

Ascofuranone (AF), a meroterpenoid isolated from various filamentous fungi, including Acremonium egyptiacum , has been reported as a potential lead candidate for drug development against parasites and cancer. In this study, we demonstrated that AF and its derivatives are potent anthelminthic agents, particularly against Echinococcus multilocularis , which is the causative agent of alveolar echinococcosis.

Funder

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01428-22

Reference36 articles.

1. Echinococcosis: Advances in the 21st Century

2. Current status of diagnosis and treatment of hepatic echinococcosis

3. Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets

4. In vivo efficacy of combination therapy with albendazole and atovaquone against primary hydatid cysts in mice

5. Mitochondrial complex III in larval stage of Echinococcus multilocularis as a potential chemotherapeutic target and in vivo efficacy of atovaquone against primary hydatid cysts

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