Calprotectin (S100A8/A9) Is an Innate Immune Effector in Experimental Periodontitis-Reference-Cited by-同舟云学术

Calprotectin (S100A8/A9) Is an Innate Immune Effector in Experimental Periodontitis

Published:2021-09-16 Issue:10 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Johnstone Karen F.¹,Wei Yuping¹,Bittner-Eddy Peter D.²,Vreeman Gerrit W.¹,Stone Ian A.¹^ORCID,Clayton Jonathan B.³,Reilly Cavan S.⁴,Walbon Travis B.¹,Wright Elisa N.¹,Hoops Susan L.³,Boyle William S.¹,Costalonga Massimo²,Herzberg Mark C.¹^ORCID

Affiliation:

1. Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA

2. Department of Developmental and Surgical Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA

3. BioTechnology Institute, Computer Science and Engineering, University of Minnesota, Saint Paul, Minnesota, USA

4. Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA

Abstract

Upregulated in inflammation, calprotectin (complexed S100A8 and S100A9; S100A8/A9) functions as an innate immune effector molecule, promoting inflammation, and also as an antimicrobial protein. We hypothesized that antimicrobial S100A8/A9 would mitigate change to the local microbial community and promote resistance to experimental periodontitis in vivo .

Funder

University of Minnesota

HHS | NIH | NIH Office of the Director

UMN | Academic Health Center, University of Minnesota

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00122-21

Reference107 articles.

1. Recent epidemiologic trends in periodontitis in the USA