Cellular Recognition of Mycobacterium tuberculosis ESAT-6 and KatG Peptides in Systemic Sarcoidosis-Reference-Cited by-同舟云学术

Cellular Recognition of Mycobacterium tuberculosis ESAT-6 and KatG Peptides in Systemic Sarcoidosis

Published:2007-01 Issue:1 Volume:75 Page:527-530
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Drake Wonder P.¹,Dhason Mary S.²,Nadaf Michele¹,Shepherd Bryan E.³,Vadivelu Sangeetha¹,Hajizadeh Rana¹,Newman Lee S.⁴⁵,Kalams Spyros A.¹⁶

Affiliation:

1. Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee

2. Department of Biology, Texas A&M University, College Station, Texas

3. Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee

4. Department of Preventive Medicine and Biometrics

5. Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado

6. Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee

Abstract

ABSTRACT Sarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides from peripheral blood mononuclear cells from 15/26 sarcoidosis, 1/24 purified-protein-derivative-negative (PPD−) ( P < 0.0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects ( P = 0.21). This finding provides immunologic links between mycobacteria and systemic sarcoidosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00732-06

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