Multiple-Site SUMOylation of FMDV 3C Protease and Its Negative Role in Viral Replication-Reference-Cited by-同舟云学术

Multiple-Site SUMOylation of FMDV 3C Protease and Its Negative Role in Viral Replication

Published:2022-09-14 Issue:17 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wu Xiangju¹²,Hu Yue¹²,Sui Chao¹²,Pan Li³,Yoo Dongwan⁴^ORCID,Miller Laura C.⁵^ORCID,Lee Changhee⁶,Cong Xiaoyan¹²,Li Juntong¹²,Du Yijun¹²^ORCID,Qi Jing¹²

Affiliation:

1. Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, Shandong, China

2. Key Laboratory of Livestock and Poultry Multi-omics of MARA, Jinan, Shandong, China

3. State Key Laboratory of Veterinary Etiological Biology/National Foot and Mouth Disease Reference Laboratory/Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China

4. Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

5. Virus and Prion Research Unit, National Animal Disease Center, United States Department of Agriculture, Agricultural Research Service, Ames, Iowa, USA

6. College of Veterinary Medicine and Virus Vaccine Research Center, Gyeongsang National University, Jinju, Republic of Korea

Abstract

FMD is a highly contagious and economically important disease in cloven-hoofed animals. SUMOylation, the covalent linkage of a small ubiquitin-like protein to a variety of substrate proteins, has emerged as an important posttranslational modification that plays multiple roles in diverse biological processes.

Funder

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Agriculture and Food Research Initiative (AFRI) Competitive Grant

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00612-22

Reference55 articles.

1. The Structure of Foot-and-Mouth Disease Virus

2. Foot-and-Mouth Disease

3. Translation and Replication of FMDV RNA

4. Molecular basis of pathogenesis of FMDV

5. Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease