Chloride Ions Are Required for Thermosipho africanus MurJ Function-Reference-Cited by-同舟云学术

Chloride Ions Are Required for Thermosipho africanus MurJ Function

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Kumar Sujeet¹,Mollo Aurelio²,Rubino Frederick A.²,Kahne Daniel²³⁴^ORCID,Ruiz Natividad¹^ORCID

Affiliation:

1. Department of Microbiology, The Ohio State University, Columbus, Ohio, USA

2. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA

3. Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA

4. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

Abstract

The biosynthetic pathway of the peptidoglycan cell wall is one of the most favorable targets for antibiotic development. Lipid II, the lipid-linked PG precursor, is made in the inner leaflet of the cytoplasmic membrane and then transported by the MurJ flippase so that it can be used to build the peptidoglycan cell wall.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00089-23

Reference22 articles.

1. The Bacterial Cell Wall: From Lipid II Flipping to Polymerization

2. Peptidoglycan: Structure, Synthesis, and Regulation

3. Growth and Division of the Peptidoglycan Matrix

4. MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis

5. Bioinformatics identification of MurJ (MviN) as the peptidoglycan lipid II flippase inEscherichia coli

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Genetic interaction mapping reveals functional relationships between peptidoglycan endopeptidases and carboxypeptidases;PLOS Genetics;2024-04-10