Imprinted Anti-Hemagglutinin and Anti-Neuraminidase Antibody Responses after Childhood Infections of A(H1N1) and A(H1N1)pdm09 Influenza Viruses

Author:

Daulagala Pavithra1,Mann Brian R.2,Leung Kathy1345,Lau Eric H. Y.134,Yung Louise1,Lei Ruipeng6,Nizami Sarea I. N.1,Wu Joseph T.134,Chiu Susan S.7,Daniels Rodney S.8ORCID,Wu Nicholas C.6ORCID,Wentworth David2,Peiris Malik139ORCID,Yen Hui-Ling1ORCID

Affiliation:

1. School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China

2. WHO Collaborating Center for Surveillance, Epidemiology and Control of Influenza, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

3. WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China

4. Laboratory of Data Discovery for Health Limited (D24H), Hong Kong Science Park, Hong Kong SAR, China

5. University of Hong Kong, Shenzhen Hospital, Shenzhen, China

6. Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

7. Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital and Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China

8. Francis Crick Institute, Crick Worldwide Influenza Centre, WHO Collaborating Centre for Reference and Research on Influenza, London, UK

9. Centre for Immunology and Infection (C2I), Hong Kong Science Park, Hong Kong SAR, China

Abstract

Seasonal influenza vaccines have aimed to generate neutralizing anti-HA antibodies for protection since licensure. More recently, anti-NA antibodies have been established as an additional correlate of protection.

Funder

Research Grant Council, Hong Kong

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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