Affiliation:
1. Laboratório de Genética Molecular, Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa, Oeiras, Portugal
2. Laboratory of Microbiology, The Rockefeller University, New York, New York 10021
Abstract
ABSTRACT
Forty-one methicillin-resistant
Staphylococcus aureus
(MRSA) hospital isolates that clearly differed from the six major pandemic clones of MRSA in pulsed-field gel electrophoresis type,
mecA
and Tn
554
polymorphism, and epidemic behavior were selected from an international strain collection for more detailed characterization.
SpaA
typing, multilocus sequence typing, and SCC
mec
(staphylococcal cassette chromosome
mec
) typing demonstrated extensive diversity among these sporadic isolates both in genetic background and also in the structure of the associated SCC
mec
elements. Nevertheless, the isolates could be grouped into restricted clonal complexes by using the BURST (i.e., based upon related sequence types) program algorithm, which predicted that most sporadic MRSA isolates evolved from pandemic MRSA clones. Several of the sporadic MRSA resembled community-acquired MRSA isolates in properties that included a relatively limited multiresistance pattern, faster growth rates, diversity of genetic backgrounds, and a frequent association with SCC
mec
type IV.
Publisher
American Society for Microbiology
Cited by
123 articles.
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