The Vaccinia Virus I7L Gene Product Is The Core Protein Proteinase-Reference-Cited by-同舟云学术

The Vaccinia Virus I7L Gene Product Is The Core Protein Proteinase

Published:2002-09 Issue:17 Volume:76 Page:8973-8976
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Byrd Chelsea M.¹,Bolken Tove' C.²,Hruby Dennis E.³²

Affiliation:

1. Molecular and Cellular Biology Program

2. SIGA Technologies, Inc., Corvallis, Oregon 97333

3. Department of Microbiology, Oregon State University, Corvallis, Oregon 97331

Abstract

ABSTRACT Maturation of vaccinia virus (VV) core proteins is required for the production of infectious virions. The VV G1L and I7L gene products are the leading candidates for the viral core protein proteinase (vCPP). Using transient-expression assays, data were obtained to demonstrate that the I7L gene product and its encoded cysteine proteinase activity are responsible for vCPP activity.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.76.17.8973-8976.2002

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