Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China

Author:

Yu Hua1,Qu Fen2,Shan Bin3,Huang Bin4,Jia Wei5,Chen Cha6,Li Aiqing7,Miao Minhui7,Zhang Xin1,Bao Chunmei2,Xu Yunmin3,Chavda Kalyan D.8,Tang Yi-Wei9ORCID,Kreiswirth Barry N.8,Du Hong7,Chen Liang8

Affiliation:

1. Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

2. The Center of Clinical Diagnosis Laboratory, 302 Hospital of PLA, Beijing, China

3. Department of Laboratory Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China

4. Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

5. Center of Medical Laboratory, the General Hospital of Ningxia Medical University, Yinchuan, China

6. Department of Laboratory Medicine, The Traditional Chinese Medical Hospital of Guangdong, Guangzhou, Guangdong, China

7. Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China

8. Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA

9. Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

Abstract

ABSTRACT The spread of the plasmid-mediated colistin resistance gene, mcr-1 , into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1 -harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1 -harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first description of chromosomal integration of mcr-1 into a carbapenem-resistant E. coli strain.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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