Novel Synergies and Isolate Specificities in the Drug Interaction Landscape of Mycobacterium abscessus-Reference-Cited by-同舟云学术

Novel Synergies and Isolate Specificities in the Drug Interaction Landscape of Mycobacterium abscessus

Published:2023-07-18 Issue:7 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Van Nhi¹²,Degefu Yonatan N.¹²,Leus Pathricia A.¹³,Larkins-Ford Jonah¹²³,Klickstein Jacob³,Maurer Florian P.⁴⁵,Stone David⁶,Poonawala Husain²⁶,Thorpe Cheleste M.²⁶,Smith Trever C.¹²,Aldridge Bree B.¹²³⁷^ORCID

Affiliation:

1. Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA

2. Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance, Boston, Massachusetts, USA

3. Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, USA

4. Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

5. National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Borstel, Germany

6. Division of Geographic Medicine and Infectious Diseases, Department of Medicine, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA

7. Department of Biomedical Engineering, Tufts University School of Engineering, Medford, Massachusetts, USA

Abstract

Mycobacterium abscessus infections are difficult to treat and are often considered untreatable without tissue resection. Due to the intrinsic drug-resistant nature of the bacteria, combination therapy of three or more antibiotics is recommended.

Funder

Mukoviszidose Institut gGmbH

HHS | NIH | National Institute of General Medical Sciences

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00090-23

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