Viral and Cellular Factors Leading to the Loss of CD4 Homeostasis in HIV-1 Viremic Nonprogressors-Reference-Cited by-同舟云学术

Viral and Cellular Factors Leading to the Loss of CD4 Homeostasis in HIV-1 Viremic Nonprogressors

Published:2022-01-12 Issue:1 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Colomer-Lluch Marta¹²,Kilpelainen Athina¹,Pernas María³,Peña Ruth¹,Ouchi Dan¹,Jimenez-Moyano Esther¹,Dalmau Judith¹,Casado Concepción³,López-Galíndez Cecilio³,Clotet Bonaventura¹⁴⁵,Martinez-Picado Javier¹²⁵⁶^ORCID,Prado Julia G.¹²^ORCID

Affiliation:

1. IrsiCaixa AIDS Research Institute, Badalona, Spain

2. Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain

3. Unidad de Virología Molecular, Laboratorio de Referencia e Investigación en Retrovirus, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain

4. Infectious Diseases Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain

5. University of Vic – Central University of Catalonia (UVic-UCC), Vic, Spain

6. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain

Abstract

The mechanism behind nonpathogenic human immunodeficiency virus type 1 (HIV-1) infection remains poorly understood, mainly because of the very low frequency of viremic nonprogressors (VNPs). Here, we report two cases of VNPs who experienced the loss of CD4 + T-cell homeostasis (LoH) after more than 13 years of HIV-1 infection.

Funder

Gilead Sciences

La Caixa Foundation

Agency for Management of University and Research Grants

EC | European Regional Development Fund

Spanish Ministry of Science and Innovation

MEC | Instituto de Salud Carlos III

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01499-21

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